<p>This group of enzymes represents a large metal dependent hydrolase superfamily [<cite idref="PUB00005750"/>]. The family includes adenine deaminase (<db_xref db="EC" dbkey="3.5.4.2"/>) that hydrolyses adenine to form hypoxanthine and ammonia. The adenine deaminase reaction is important for adenine utilization as a purine and also as a nitrogen source [<cite idref="PUB00004994"/>]. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases (<db_xref db="EC" dbkey="3.5.1.25"/>). These enzymes catalyse the reaction: <reaction> N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</reaction>This family includes dihydroorotase and urease which belong to MEROPS peptidase family M38 (beta-aspartyl dipeptidase, clan MJ), where they are classified as non-peptidase homologs. </p> Amidohydrolase 1